5wy0

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'''Unreleased structure'''
 
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The entry 5wy0 is ON HOLD until Paper Publication
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==Crystal structure of the methyltranferase domain of human HEN1 in complex with AdoMet==
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<StructureSection load='5wy0' size='340' side='right' caption='[[5wy0]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5wy0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WY0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WY0 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wy0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wy0 OCA], [http://pdbe.org/5wy0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wy0 RCSB], [http://www.ebi.ac.uk/pdbsum/5wy0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wy0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/HENMT_HUMAN HENMT_HUMAN]] Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis (By similarity).
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__TOC__
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</StructureSection>
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[[Category: Huang, Y]]
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[[Category: Ma, J B]]
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[[Category: Peng, L]]
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[[Category: Wu, L G]]
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[[Category: Adomet]]
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[[Category: Rna methyltranferase]]
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[[Category: Transferase]]

Revision as of 06:56, 17 January 2018

Crystal structure of the methyltranferase domain of human HEN1 in complex with AdoMet

5wy0, resolution 2.00Å

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