6f1y
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Dynein light intermediate chain region of the dynein tail/dynactin/BICDR1 complex== | |
| - | + | <StructureSection load='6f1y' size='340' side='right' caption='[[6f1y]], [[Resolution|resolution]] 3.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6f1y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F1Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F1Y FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6f1t|6f1t]], [[6f1u|6f1u]], [[6f1v|6f1v]]</td></tr> |
| - | [[Category: Lau, C | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f1y OCA], [http://pdbe.org/6f1y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f1y RCSB], [http://www.ebi.ac.uk/pdbsum/6f1y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f1y ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/DYHC1_HUMAN DYHC1_HUMAN]] Autosomal dominant childhood-onset proximal spinal muscular atrophy without contractures;Autosomal dominant non-syndromic intellectual disability;Autosomal dominant Charcot-Marie-Tooth disease type 2O. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DYHC1_HUMAN DYHC1_HUMAN]] Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074).<ref>PMID:27462074</ref> [[http://www.uniprot.org/uniprot/DC1L2_HUMAN DC1L2_HUMAN]] Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Carter, A P]] | ||
| + | [[Category: Elshenawy, M M]] | ||
| + | [[Category: Lau, C K]] | ||
| + | [[Category: Morales-Rios, E]] | ||
[[Category: Motz, C]] | [[Category: Motz, C]] | ||
| - | [[Category: Carter, A.P]] | ||
| - | [[Category: Elshenawy, M.M]] | ||
[[Category: Urnavicius, L]] | [[Category: Urnavicius, L]] | ||
| - | [[Category: Morales-Rios, E]] | ||
[[Category: Yildiz, A]] | [[Category: Yildiz, A]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Cryo-em]] | ||
| + | [[Category: Motor protein]] | ||
Revision as of 07:09, 17 January 2018
Dynein light intermediate chain region of the dynein tail/dynactin/BICDR1 complex
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Categories: Carter, A P | Elshenawy, M M | Lau, C K | Morales-Rios, E | Motz, C | Urnavicius, L | Yildiz, A | Complex | Cryo-em | Motor protein
