6f3a
From Proteopedia
(Difference between revisions)
m (Protected "6f3a" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of a single dynein tail domain bound to dynactin and BICD2N== | |
| - | + | <StructureSection load='6f3a' size='340' side='right' caption='[[6f3a]], [[Resolution|resolution]] 8.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6f3a]] is a 36 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F3A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F3A FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f3a OCA], [http://pdbe.org/6f3a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f3a RCSB], [http://www.ebi.ac.uk/pdbsum/6f3a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f3a ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/DYHC1_HUMAN DYHC1_HUMAN]] Autosomal dominant childhood-onset proximal spinal muscular atrophy without contractures;Autosomal dominant non-syndromic intellectual disability;Autosomal dominant Charcot-Marie-Tooth disease type 2O. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DC1I2_HUMAN DC1I2_HUMAN]] Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes. [[http://www.uniprot.org/uniprot/ACTB_PIG ACTB_PIG]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. [[http://www.uniprot.org/uniprot/DC1L2_HUMAN DC1L2_HUMAN]] Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. [[http://www.uniprot.org/uniprot/DYHC1_HUMAN DYHC1_HUMAN]] Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074).<ref>PMID:27462074</ref> [[http://www.uniprot.org/uniprot/DLRB1_HUMAN DLRB1_HUMAN]] Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Sus scrofa]] | ||
| + | [[Category: Carter, A P]] | ||
| + | [[Category: Elshenawy, M M]] | ||
| + | [[Category: Lau, C K]] | ||
| + | [[Category: Morales-Rios, E]] | ||
[[Category: Motz, C]] | [[Category: Motz, C]] | ||
| - | [[Category: Carter, A.P]] | ||
| - | [[Category: Elshenawy, M.M]] | ||
[[Category: Urnavicius, L]] | [[Category: Urnavicius, L]] | ||
| - | [[Category: Lau, C.K]] | ||
| - | [[Category: Morales-Rios, E]] | ||
[[Category: Yildiz, A]] | [[Category: Yildiz, A]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Dynein/dynactin/bicd2]] | ||
| + | [[Category: Motor protein]] | ||
| + | [[Category: Tdb]] | ||
Revision as of 07:09, 17 January 2018
Cryo-EM structure of a single dynein tail domain bound to dynactin and BICD2N
| |||||||||||
