4bm8
From Proteopedia
(Difference between revisions)
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<StructureSection load='4bm8' size='340' side='right' caption='[[4bm8]], [[Resolution|resolution]] 0.96Å' scene=''> | <StructureSection load='4bm8' size='340' side='right' caption='[[4bm8]], [[Resolution|resolution]] 0.96Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4bm8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BM8 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4bm8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BM8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BM8 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A6J:(3-DEOXY-3-(2,3,5,6-TETRA-FLUORO-4-METHOXY-BENZAMIDO)-B-D-GALACTOPYRANOSYL)-(3-DEOXY-3-(2,3,5,6-TETRA-FLUORO-4-METHOXY-BENZAMIDO)-2-O-SULFO-B-D-GALACTOPYRANOSYL)-SULFIDE'>A6J</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A6J:(3-DEOXY-3-(2,3,5,6-TETRA-FLUORO-4-METHOXY-BENZAMIDO)-B-D-GALACTOPYRANOSYL)-(3-DEOXY-3-(2,3,5,6-TETRA-FLUORO-4-METHOXY-BENZAMIDO)-2-O-SULFO-B-D-GALACTOPYRANOSYL)-SULFIDE'>A6J</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bli|4bli]], [[4blj|4blj]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bli|4bli]], [[4blj|4blj]]</td></tr> | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref> | [[http://www.uniprot.org/uniprot/LEG3_HUMAN LEG3_HUMAN]] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.<ref>PMID:15181153</ref> <ref>PMID:19594635</ref> <ref>PMID:19616076</ref> | ||
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| - | ==See Also== | ||
| - | *[[Galectin|Galectin]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Engstrom, O]] | [[Category: Engstrom, O]] | ||
[[Category: Hakansson, M]] | [[Category: Hakansson, M]] | ||
Revision as of 07:45, 17 January 2018
Galectin-3c in complex with Bisamido-thiogalactoside derivate 3
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