5y6k
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Human serum trnasferrin bound to a fluorescent probe== | |
| + | <StructureSection load='5y6k' size='340' side='right' caption='[[5y6k]], [[Resolution|resolution]] 2.86Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5y6k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y6K FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8R6:(2S)-6-[2-(7-azido-4-methyl-2-oxidanylidene-chromen-3-yl)ethanoylamino]-2-[bis(2-hydroxy-2-oxoethyl)amino]hexanoic+acid'>8R6</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y6k OCA], [http://pdbe.org/5y6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y6k RCSB], [http://www.ebi.ac.uk/pdbsum/5y6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y6k ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[http://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Porphyromonas gingivalis is a key oral anaerobic bacterium involved in human periodontitis, which may affect up to 15% adults worldwide. Using the membrane permeable fluorescent probe Fe-TRACER, we identified 17 iron-associated proteins in Porphyromonas gingivalis. We demonstrated the specific binding of the probe towards iron-associated proteins using transferrin as an example and provided an X-ray structure of the fluorescent probe-bound transferrin. Our study provides a basis for the understanding of iron homeostasis in pathogens, and our approach based on the integration of fluorescence imaging with proteomics and bioinformatics can be readily extended to mine other metalloproteomes in microbials. | ||
| - | + | Tracking iron-associated proteomes in pathogens by a fluorescence approach.,Jiang N, Cheng T, Wang M, Chan GC, Jin L, Li H, Sun H Metallomics. 2018 Jan 11. doi: 10.1039/c7mt00275k. PMID:29323384<ref>PMID:29323384</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5y6k" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Chan, G C.F]] | ||
| + | [[Category: Cheng, T]] | ||
[[Category: Jiang, N]] | [[Category: Jiang, N]] | ||
| - | [[Category: Sun, H]] | ||
[[Category: Jin, L]] | [[Category: Jin, L]] | ||
| - | [[Category: | + | [[Category: Li, H]] |
| - | [[Category: | + | [[Category: Sun, H]] |
| + | [[Category: Wang, M]] | ||
| + | [[Category: Fluorescent]] | ||
| + | [[Category: Metal transport]] | ||
| + | [[Category: Probe]] | ||
| + | [[Category: Transferrin]] | ||
Revision as of 18:27, 24 January 2018
Human serum trnasferrin bound to a fluorescent probe
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Categories: Homo sapiens | Chan, G C.F | Cheng, T | Jiang, N | Jin, L | Li, H | Sun, H | Wang, M | Fluorescent | Metal transport | Probe | Transferrin
