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6b3y
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the PH-like domain from DENND3== | |
| - | + | <StructureSection load='6b3y' size='340' side='right' caption='[[6b3y]], [[Resolution|resolution]] 1.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6b3y]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B3Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6B3Y FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6b3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b3y OCA], [http://pdbe.org/6b3y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6b3y RCSB], [http://www.ebi.ac.uk/pdbsum/6b3y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6b3y ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DEND3_MOUSE DEND3_MOUSE]] Guanine nucleotide exchange factor (GEF) activating Rab12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab12 into its active GTP-bound form. Regulates autophagy in response to starvation through Rab12 activation (PubMed:24719330, PubMed:25925668, PubMed:28249939). Starvation leads to ULK1/2-dependent phosphorylation of Ser-554 and Ser-572, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards Rab12 (PubMed:25925668). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:21718402, PubMed:24719330). Starvation also induces phosphorylation at Tyr-940, which leads to up-regulated GEF activity and initiates autophagy (PubMed:28249939).<ref>PMID:21718402</ref> <ref>PMID:24719330</ref> <ref>PMID:25925668</ref> <ref>PMID:28249939</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Beaugrand, M]] | ||
| + | [[Category: Gehring, K]] | ||
| + | [[Category: Kozlov, G]] | ||
| + | [[Category: McPherson, P S]] | ||
| + | [[Category: Menade, M]] | ||
| + | [[Category: Pan, T]] | ||
| + | [[Category: Xu, J]] | ||
| + | [[Category: Autophagy]] | ||
| + | [[Category: Guanine nucleotide exchange factor]] | ||
| + | [[Category: Ph-like fold]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 18:29, 24 January 2018
Crystal structure of the PH-like domain from DENND3
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