6byb

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m (Protected "6byb" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6byb is ON HOLD
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==Crystal structure of L3MBTL1 MBT Domain with MBK14970==
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<StructureSection load='6byb' size='340' side='right' caption='[[6byb]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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Authors: DONG, A., DOBROVETSKY, E., NICHOLSON, B., COX, C., FISCHER, C., ARMACOST, K., SANDERS, J., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6byb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BYB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BYB FirstGlance]. <br>
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Description: Crystal structure of L3MBTL1 MBT Domain with MBK14970
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EC7:(S)-N-(cyclopropylmethyl)-N~2~-methyl-N-[2-methyl-2-(1-methylpiperidin-4-yl)propyl]alaninamide'>EC7</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6byb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6byb OCA], [http://pdbe.org/6byb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6byb RCSB], [http://www.ebi.ac.uk/pdbsum/6byb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6byb ProSAT]</span></td></tr>
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[[Category: Cox, C]]
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</table>
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[[Category: Arrowsmith, C.H]]
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== Function ==
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[[Category: Dong, A]]
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[[http://www.uniprot.org/uniprot/LMBL1_HUMAN LMBL1_HUMAN]] Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.<ref>PMID:17540172</ref> <ref>PMID:18408754</ref> <ref>PMID:20870719</ref> <ref>PMID:20870725</ref>
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[[Category: Brown, P.J]]
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== References ==
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[[Category: Fischer, C]]
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<references/>
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[[Category: Nicholson, B]]
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__TOC__
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[[Category: Edwards, A.M]]
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</StructureSection>
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[[Category: Dobrovetsky, E]]
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[[Category: ARMACOST, K]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Arrowsmith, C H]]
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[[Category: Sanders, J]]
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[[Category: BROWN, P J]]
[[Category: Bountra, C]]
[[Category: Bountra, C]]
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[[Category: Armacost, K]]
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[[Category: COX, C]]
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[[Category: DOBROVETSKY, E]]
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[[Category: DONG, A]]
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[[Category: Edwards, A M]]
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[[Category: FISCHER, C]]
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[[Category: NICHOLSON, B]]
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[[Category: SANDERS, J]]
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[[Category: Structural genomic]]
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[[Category: L3mbtl1]]
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[[Category: Sgc]]
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[[Category: Transcription]]

Revision as of 18:30, 24 January 2018

Crystal structure of L3MBTL1 MBT Domain with MBK14970

6byb, resolution 1.74Å

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