2vh1

From Proteopedia

(Difference between revisions)

Revision as of 19:03, 24 January 2018

Crystal structure of bacterial cell division protein FtsQ from E.coli

Structural highlights

2vh1 is a 2 chain structure with sequence from "bacillus_coli"_migula_1895 "bacillus coli" migula 1895. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Bacterial cytokinesis requires the divisome, a complex of proteins that co-ordinates the invagination of the cytoplasmic membrane, inward growth of the peptidoglycan layer and the outer membrane. Assembly of the cell division proteins is tightly regulated and the order of appearance at the future division site is well organized. FtsQ is a highly conserved component of the divisome among bacteria that have a cell wall, where it plays a central role in the assembly of early and late cell division proteins. Here, we describe the crystal structure of the major, periplasmic domain of FtsQ from Escherichia coli and Yersinia enterocolitica. The crystal structure reveals two domains; the alpha-domain has a striking similarity to polypeptide transport-associated (POTRA) domains and the C-terminal beta-domain forms an extended beta-sheet overlaid by two, slightly curved alpha-helices. Mutagenesis experiments demonstrate that two functions of FtsQ, localization and recruitment, occur in two separate domains. Proteins that localize FtsQ need the second beta-strand of the POTRA domain and those that are recruited by FtsQ, like FtsL/FtsB, require the surface formed by the tip of the last alpha-helix and the two C-terminal beta-strands. Both domains act together to accomplish the role of FtsQ in linking upstream and downstream cell division proteins within the divisome.

Structural and mutational analysis of the cell division protein FtsQ.,van den Ent F, Vinkenvleugel TM, Ind A, West P, Veprintsev D, Nanninga N, den Blaauwen T, Lowe J Mol Microbiol. 2008 Apr;68(1):110-23. Epub 2008 Feb 26. PMID:18312270^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ van den Ent F, Vinkenvleugel TM, Ind A, West P, Veprintsev D, Nanninga N, den Blaauwen T, Lowe J. Structural and mutational analysis of the cell division protein FtsQ. Mol Microbiol. 2008 Apr;68(1):110-23. Epub 2008 Feb 26. PMID:18312270 doi:http://dx.doi.org/10.1111/j.1365-2958.2008.06141.x

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vh1"

@@ Line 1: / Line 1: @@
-==CRYSTAL STRUCTURE OF BACTERIAL CELL DIVISION PROTEIN FTSQ FROM E.COLI==
+==Crystal structure of bacterial cell division protein FtsQ from E.coli==
 <StructureSection load='2vh1' size='340' side='right' caption='[[2vh1]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[2vh1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VH1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VH1 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vh1 OCA], [http://pdbe.org/2vh1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2vh1 PDBsum]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vh1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vh1 OCA], [http://pdbe.org/2vh1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vh1 RCSB], [http://www.ebi.ac.uk/pdbsum/2vh1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vh1 ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==
@@ Line 9: / Line 10: @@
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vh/2vh1_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vh/2vh1_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 29: / Line 30: @@
 </StructureSection>
 [[Category: Bacillus coli migula 1895]]
-[[Category: Blaauwen, T Den]]
+[[Category: Blaauwen, T den]]
-[[Category: Ent, F Van Den]]
+[[Category: Ent, F van den]]
 [[Category: Ind, A]]
 [[Category: Lowe, J]]

2vh1

From Proteopedia

Revision as of 19:03, 24 January 2018

Crystal structure of bacterial cell division protein FtsQ from E.coli

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox