4akv
From Proteopedia
(Difference between revisions)
| Line 9: | Line 9: | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/SNX33_HUMAN SNX33_HUMAN]] Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.<ref>PMID:18353773</ref> <ref>PMID:18419754</ref> <ref>PMID:19487689</ref> <ref>PMID:20964629</ref> <ref>PMID:21048941</ref> <ref>PMID:22718350</ref> | [[http://www.uniprot.org/uniprot/SNX33_HUMAN SNX33_HUMAN]] Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.<ref>PMID:18353773</ref> <ref>PMID:18419754</ref> <ref>PMID:19487689</ref> <ref>PMID:20964629</ref> <ref>PMID:21048941</ref> <ref>PMID:22718350</ref> | ||
| - | |||
| - | ==See Also== | ||
| - | *[[Sorting nexin|Sorting nexin]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 19: | Line 16: | ||
[[Category: Arrowsmith, C]] | [[Category: Arrowsmith, C]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
| - | [[Category: Delft, F | + | [[Category: Delft, F von]] |
[[Category: Edwards, A]] | [[Category: Edwards, A]] | ||
[[Category: Filippakopoulos, P]] | [[Category: Filippakopoulos, P]] | ||
Revision as of 19:45, 24 January 2018
Crystal structure of human sorting nexin 33 (SNX33)
| |||||||||||
