4dyl
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/FES_HUMAN FES_HUMAN]] Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.<ref>PMID:2656706</ref> <ref>PMID:8955135</ref> <ref>PMID:11509660</ref> <ref>PMID:15302586</ref> <ref>PMID:15485904</ref> <ref>PMID:16455651</ref> <ref>PMID:17595334</ref> <ref>PMID:18046454</ref> <ref>PMID:19051325</ref> <ref>PMID:19082481</ref> <ref>PMID:19001085</ref> <ref>PMID:20111072</ref> <ref>PMID:21563194</ref> | [[http://www.uniprot.org/uniprot/FES_HUMAN FES_HUMAN]] Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28.<ref>PMID:2656706</ref> <ref>PMID:8955135</ref> <ref>PMID:11509660</ref> <ref>PMID:15302586</ref> <ref>PMID:15485904</ref> <ref>PMID:16455651</ref> <ref>PMID:17595334</ref> <ref>PMID:18046454</ref> <ref>PMID:19051325</ref> <ref>PMID:19082481</ref> <ref>PMID:19001085</ref> <ref>PMID:20111072</ref> <ref>PMID:21563194</ref> | ||
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| - | ==See Also== | ||
| - | *[[Tyrosine kinase|Tyrosine kinase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Edwards, A]] | [[Category: Edwards, A]] | ||
[[Category: Elkins, J]] | [[Category: Elkins, J]] | ||
| + | [[Category: Filippakopoulos, P]] | ||
[[Category: Knapp, S]] | [[Category: Knapp, S]] | ||
[[Category: Krojer, T]] | [[Category: Krojer, T]] | ||
| - | [[Category: P., Filippakopoulos]] | ||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
[[Category: Salah, E]] | [[Category: Salah, E]] | ||
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[[Category: Bcr]] | [[Category: Bcr]] | ||
[[Category: Crk-associated substrate]] | [[Category: Crk-associated substrate]] | ||
| + | [[Category: Sgc]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 19:51, 24 January 2018
F-BAR domain of human FES tyrosine kinase
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