4mya
From Proteopedia
(Difference between revisions)
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<StructureSection load='4mya' size='340' side='right' caption='[[4mya]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='4mya' size='340' side='right' caption='[[4mya]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4mya]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MYA FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4mya]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis_(strain_ames) Bacillus anthracis (strain ames)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MYA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MYA FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2EY:4-{(1R)-1-[1-(4-CHLOROPHENYL)-1H-1,2,3-TRIAZOL-4-YL]ETHOXY}QUINOLIN-2(1H)-ONE'>2EY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2EY:4-{(1R)-1-[1-(4-CHLOROPHENYL)-1H-1,2,3-TRIAZOL-4-YL]ETHOXY}QUINOLIN-2(1H)-ONE'>2EY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3stb|3stb]], [[3std|3std]], [[3sub|3sub]], [[4mjm|4mjm]], [[4mxs|4mxs]], [[4my1|4my1]], [[4my8|4my8]], [[4my9|4my9]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3stb|3stb]], [[3std|3std]], [[3sub|3sub]], [[4mjm|4mjm]], [[4mxs|4mxs]], [[4my1|4my1]], [[4my8|4my8]], [[4my9|4my9]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">guaB, BA_0008, BAS0011, GBAA_0008 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis (strain Ames)])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mya OCA], [http://pdbe.org/4mya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mya RCSB], [http://www.ebi.ac.uk/pdbsum/4mya PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mya ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mya OCA], [http://pdbe.org/4mya PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mya RCSB], [http://www.ebi.ac.uk/pdbsum/4mya PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mya ProSAT]</span></td></tr> | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/Q81W29_BACAN Q81W29_BACAN]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[HAMAP-Rule:MF_01964] | [[http://www.uniprot.org/uniprot/Q81W29_BACAN Q81W29_BACAN]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity).[HAMAP-Rule:MF_01964] | ||
| - | |||
| - | ==See Also== | ||
| - | *[[Inosine monophosphate dehydrogenase|Inosine monophosphate dehydrogenase]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: IMP dehydrogenase]] | [[Category: IMP dehydrogenase]] | ||
[[Category: Anderson, W F]] | [[Category: Anderson, W F]] | ||
| + | [[Category: CSGID]] | ||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
| - | [[Category: Csgid]] | ||
[[Category: Gorla, S K]] | [[Category: Gorla, S K]] | ||
[[Category: Gu, M]] | [[Category: Gu, M]] | ||
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[[Category: Makowska-Grzyska, M]] | [[Category: Makowska-Grzyska, M]] | ||
[[Category: Alpha-beta structure]] | [[Category: Alpha-beta structure]] | ||
| + | [[Category: Csgid]] | ||
[[Category: National institute of allergy and infectious disease]] | [[Category: National institute of allergy and infectious disease]] | ||
[[Category: Niaid]] | [[Category: Niaid]] | ||
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | [[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | ||
[[Category: Tim barrel]] | [[Category: Tim barrel]] | ||
Revision as of 20:12, 24 January 2018
Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase with an Internal Deletion of the CBS Domain from Bacillus anthracis str. Ames complexed with inhibitor A110
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Categories: IMP dehydrogenase | Anderson, W F | CSGID | Structural genomic | Gorla, S K | Gu, M | Hedstrom, L | Joachimiak, A | Kim, Y | Makowska-Grzyska, M | Alpha-beta structure | Csgid | National institute of allergy and infectious disease | Niaid | Oxidoreductase-oxidoreductase inhibitor complex | Tim barrel
