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Syntrophin
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | Syn is characterized by a plekstrin homology domain(PH) which is split by a PDZ domain and a C-terminal Syn unique domain. Syn binds the neuronal NOS β-finger via its binding groove<ref>PMID:10221915</ref>. | + | Syn is characterized by a plekstrin homology domain(PH) which is split by a PDZ domain and a C-terminal Syn unique domain. <scene name='77/777075/Cv/2'>Syn binds the neuronal NOS</scene> β-finger via its binding groove<ref>PMID:10221915</ref>. |
</StructureSection> | </StructureSection> | ||
Revision as of 10:27, 28 January 2018
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3D Structures of syntrophin
Updated on 28-January-2018
References
- ↑ Bhat HF, Adams ME, Khanday FA. Syntrophin proteins as Santa Claus: role(s) in cell signal transduction. Cell Mol Life Sci. 2013 Jul;70(14):2533-54. doi: 10.1007/s00018-012-1233-9. Epub , 2012 Dec 21. PMID:23263165 doi:http://dx.doi.org/10.1007/s00018-012-1233-9
- ↑ Wu G, Ai T, Kim JJ, Mohapatra B, Xi Y, Li Z, Abbasi S, Purevjav E, Samani K, Ackerman MJ, Qi M, Moss AJ, Shimizu W, Towbin JA, Cheng J, Vatta M. alpha-1-syntrophin mutation and the long-QT syndrome: a disease of sodium channel disruption. Circ Arrhythm Electrophysiol. 2008 Aug;1(3):193-201. doi:, 10.1161/CIRCEP.108.769224. PMID:19684871 doi:http://dx.doi.org/10.1161/CIRCEP.108.769224
- ↑ Hillier BJ, Christopherson KS, Prehoda KE, Bredt DS, Lim WA. Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex. Science. 1999 Apr 30;284(5415):812-5. PMID:10221915
