5uii
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==structure of DHFR with bound buformin and NADP== | |
| - | + | <StructureSection load='5uii' size='340' side='right' caption='[[5uii]], [[Resolution|resolution]] 1.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5uii]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UII OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UII FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BFR:N-butyl-N-(diaminomethylidene)guanidine'>BFR</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5uih|5uih]], [[5uio|5uio]], [[5uip|5uip]]</td></tr> |
| - | [[Category: London, R | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr> |
| - | [[Category: Pedersen, L | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uii OCA], [http://pdbe.org/5uii PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uii RCSB], [http://www.ebi.ac.uk/pdbsum/5uii PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uii ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dihydrofolate reductase]] | ||
| + | [[Category: London, R E]] | ||
| + | [[Category: Pedersen, L C]] | ||
| + | [[Category: Buformin]] | ||
| + | [[Category: Dhfr]] | ||
| + | [[Category: Nadp]] | ||
| + | [[Category: Oxidoreductase]] | ||
Revision as of 05:50, 31 January 2018
structure of DHFR with bound buformin and NADP
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