5uml

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m (Protected "5uml" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5uml is ON HOLD until Paper Publication
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==CRYSTAL STRUCTURE OF HUMAN MDMX IN COMPLEX WITH 12-MER PEPTIDE INHIBITOR M3==
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<StructureSection load='5uml' size='340' side='right' caption='[[5uml]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors: Marzena, P., Neelakshi, G., William, T.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5uml]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UML OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UML FirstGlance]. <br>
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Description: CRYSTAL STRUCTURE OF HUMAN MDMX IN COMPLEX WITH 12-MER PEPTIDE INHIBITOR M3
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5umm|5umm]]</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uml OCA], [http://pdbe.org/5uml PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uml RCSB], [http://www.ebi.ac.uk/pdbsum/5uml PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uml ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN]] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Marzena, P]]
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[[Category: Neelakshi, G]]
[[Category: William, T]]
[[Category: William, T]]
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[[Category: Neelakshi, G]]
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[[Category: Antitumor protein-inhibitor complex]]
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[[Category: Marzena, P]]
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[[Category: Cell cycle]]
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[[Category: Oncoprotein]]

Revision as of 05:50, 31 January 2018

CRYSTAL STRUCTURE OF HUMAN MDMX IN COMPLEX WITH 12-MER PEPTIDE INHIBITOR M3

5uml, resolution 3.00Å

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