5z10
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the mechanosensitive Piezo1 channel== | |
| - | + | <StructureSection load='5z10' size='340' side='right' caption='[[5z10]], [[Resolution|resolution]] 3.97Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5z10]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z10 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z10 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z10 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z10 OCA], [http://pdbe.org/5z10 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z10 RCSB], [http://www.ebi.ac.uk/pdbsum/5z10 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z10 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PIEZ1_MOUSE PIEZ1_MOUSE]] Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology.<ref>PMID:20813920</ref> <ref>PMID:22343900</ref> <ref>PMID:24157948</ref> <ref>PMID:24958852</ref> <ref>PMID:25119035</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chi, S]] | ||
| + | [[Category: Dong, M Q]] | ||
| + | [[Category: Gang, J]] | ||
| + | [[Category: Li, X]] | ||
| + | [[Category: Liu, W]] | ||
| + | [[Category: Wang, J]] | ||
| + | [[Category: Wang, Y]] | ||
| + | [[Category: Wu, K]] | ||
| + | [[Category: Xiao, B]] | ||
| + | [[Category: Zhang, T]] | ||
| + | [[Category: Zhao, Q]] | ||
| + | [[Category: Zhou, H]] | ||
| + | [[Category: Channel]] | ||
| + | [[Category: Mechanogating]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Piezo1]] | ||
| + | [[Category: Piezo2]] | ||
Revision as of 05:55, 31 January 2018
Structure of the mechanosensitive Piezo1 channel
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