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6c0v
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation== | |
| - | + | <StructureSection load='6c0v' size='340' side='right' caption='[[6c0v]], [[Resolution|resolution]] 3.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6c0v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C0V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C0V FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xenobiotic-transporting_ATPase Xenobiotic-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.44 3.6.3.44] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c0v OCA], [http://pdbe.org/6c0v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c0v RCSB], [http://www.ebi.ac.uk/pdbsum/6c0v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c0v ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/MDR1_HUMAN MDR1_HUMAN]] Ulcerative colitis. Disease susceptibility is associated with variations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MDR1_HUMAN MDR1_HUMAN]] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Xenobiotic-transporting ATPase]] | ||
| + | [[Category: Chen, J]] | ||
| + | [[Category: Kim, Y J]] | ||
| + | [[Category: Abc transporter]] | ||
| + | [[Category: Abcb1]] | ||
| + | [[Category: Cryo-em]] | ||
| + | [[Category: Multidrug resistance]] | ||
| + | [[Category: P-glycoprotein]] | ||
| + | [[Category: PSI, Protein structure initiative]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 05:58, 31 January 2018
Molecular structure of human P-glycoprotein in the ATP-bound, outward-facing conformation
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