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6erx
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab== | |
| - | + | <StructureSection load='6erx' size='340' side='right' caption='[[6erx]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6erx]] is a 18 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ERX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ERX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6erx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6erx OCA], [http://pdbe.org/6erx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6erx RCSB], [http://www.ebi.ac.uk/pdbsum/6erx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6erx ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TN13B_HUMAN TN13B_HUMAN]] Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.<ref>PMID:10973284</ref> Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity).<ref>PMID:10973284</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Jiang, X]] | ||
| + | [[Category: Lammens, A]] | ||
| + | [[Category: Maskos, K]] | ||
| + | [[Category: Schneider, P]] | ||
| + | [[Category: Willen, L]] | ||
| + | [[Category: Antibody]] | ||
| + | [[Category: B cell]] | ||
| + | [[Category: Baff]] | ||
| + | [[Category: Cytokine]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Immunology]] | ||
| + | [[Category: Protero]] | ||
Revision as of 06:00, 31 January 2018
Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab
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Categories: Jiang, X | Lammens, A | Maskos, K | Schneider, P | Willen, L | Antibody | B cell | Baff | Cytokine | Immune system | Immunology | Protero
