Mutation:BRCA1
From Proteopedia
(Difference between revisions)
Sequence
⎈ mutations with manual annotation;pathogenic;benign;not yet reviewed;
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* '''ToDo''': Implement Template to render ALL mutations of a given model with ConSurf colouring. | * '''ToDo''': Implement Template to render ALL mutations of a given model with ConSurf colouring. | ||
* '''ToDo''': Check if model(s) structure loaded before displaying a mutation, to enable showing other structures and back to the sequence/model interaction. Currently model(s) structure loaded only on initial page loading. | * '''ToDo''': Check if model(s) structure loaded before displaying a mutation, to enable showing other structures and back to the sequence/model interaction. Currently model(s) structure loaded only on initial page loading. | ||
| + | * '''ToDo''': extend to support more than one mutation in same residue | ||
| + | * '''ToDo''': implement bidirectional action between sequence and model | ||
| + | * '''ToDo''': display icons + text associated to the kind of mutation (echo or below applet) | ||
| + | * '''ToDo''': implement a tooltip-style text box holding additional information for each mutation | ||
| + | * '''ToDo''': implement storage of all accessory information per residue | ||
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Revision as of 09:23, 6 February 2018
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References
- ↑ Clapperton JA, Manke IA, Lowery DM, Ho T, Haire LF, Yaffe MB, Smerdon SJ. Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer. Nat Struct Mol Biol. 2004 Jun;11(6):512-8. Epub 2004 May 9. PMID:15133502 doi:10.1038/nsmb775
- ↑ Yue P, Li Z, Moult J. Loss of protein structure stability as a major causative factor in monogenic disease. J Mol Biol. 2005 Oct 21;353(2):459-73. PMID:16169011 doi:http://dx.doi.org/10.1016/j.jmb.2005.08.020
Proteopedia Page Contributors and Editors (what is this?)
Jaime Prilusky, John Moult, Lipika Ray, Joel L. Sussman, Angel Herraez
