5yp6
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==RORgamma (263-509) complexed with SRC2 and Compound 6== | |
| - | + | <StructureSection load='5yp6' size='340' side='right' caption='[[5yp6]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5yp6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YP6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YP6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4CX:N-[3-cyano-4-(2-methylpropyl)-2-(trifluoromethyl)biphenyl-4-yl]-2-[4-(ethylsulfonyl)phenyl]acetamide'>4CX</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yp6 OCA], [http://pdbe.org/5yp6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yp6 RCSB], [http://www.ebi.ac.uk/pdbsum/5yp6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yp6 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cai, W]] | ||
| + | [[Category: Gao, M]] | ||
| + | [[Category: Complex structure]] | ||
| + | [[Category: Nuclear receptor ror]] | ||
| + | [[Category: Transcription factor]] | ||
| + | [[Category: Transcription-inhibitor complex]] | ||
Revision as of 06:18, 7 February 2018
RORgamma (263-509) complexed with SRC2 and Compound 6
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