5yqg
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The structure of 14-3-3 and pNumb peptide== |
| - | + | <StructureSection load='5yqg' size='340' side='right' caption='[[5yqg]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5yqg]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YQG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YQG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5yqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5yqg OCA], [http://pdbe.org/5yqg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5yqg RCSB], [http://www.ebi.ac.uk/pdbsum/5yqg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5yqg ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/1433F_MOUSE 1433F_MOUSE]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity). [[http://www.uniprot.org/uniprot/NUMB_MOUSE NUMB_MOUSE]] Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage.<ref>PMID:10841580</ref> <ref>PMID:12410312</ref> <ref>PMID:15273690</ref> <ref>PMID:17174898</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chen, X]] | ||
| + | [[Category: Liu, Z]] | ||
| + | [[Category: Wen, W]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Non-canonical]] | ||
| + | [[Category: Peptide binding protein]] | ||
| + | [[Category: Phosphorylation]] | ||
Revision as of 06:18, 7 February 2018
The structure of 14-3-3 and pNumb peptide
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