2eb3

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|PDB= 2eb3 |SIZE=350|CAPTION= <scene name='initialview01'>2eb3</scene>, resolution 2.84&Aring;
|PDB= 2eb3 |SIZE=350|CAPTION= <scene name='initialview01'>2eb3</scene>, resolution 2.84&Aring;
|SITE= <scene name='pdbsite=AC1:Anp+Binding+Site+For+Residue+A+2001'>AC1</scene>
|SITE= <scene name='pdbsite=AC1:Anp+Binding+Site+For+Residue+A+2001'>AC1</scene>
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|LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER'>ANP</scene>
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|LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1]
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span>
|GENE= EGFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= EGFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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|RELATEDENTRY=[[2eb2|2EB2]], [[2zge|2ZGE]], [[2zgf|2ZGF]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eb3 OCA], [http://www.ebi.ac.uk/pdbsum/2eb3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2eb3 RCSB]</span>
}}
}}
'''Crystal structure of mutated EGFR kinase domain (L858R) in complex with AMPPNP'''
'''Crystal structure of mutated EGFR kinase domain (L858R) in complex with AMPPNP'''
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==Disease==
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Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]], Nonsmall cell lung cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]]
==About this Structure==
==About this Structure==
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[[Category: Yokoyama, S.]]
[[Category: Yokoyama, S.]]
[[Category: Yoshikawa, S.]]
[[Category: Yoshikawa, S.]]
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[[Category: ANP]]
 
[[Category: atp-binding]]
[[Category: atp-binding]]
[[Category: cell cycle]]
[[Category: cell cycle]]
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[[Category: tyrosine-protein kinase]]
[[Category: tyrosine-protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:37:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:46:23 2008''

Revision as of 23:46, 30 March 2008

Image:2eb3.jpg


PDB ID 2eb3

Drag the structure with the mouse to rotate
, resolution 2.84Å
Sites:
Ligands:
Gene: EGFR (Homo sapiens)
Activity: Receptor protein-tyrosine kinase, with EC number 2.7.10.1
Related: 2EB2, 2ZGE, 2ZGF


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of mutated EGFR kinase domain (L858R) in complex with AMPPNP


Disease

Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, susceptibility to OMIM:[131550]

About this Structure

2EB3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Page seeded by OCA on Mon Mar 31 02:46:23 2008

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