1ne9

From Proteopedia

(Difference between revisions)

Revision as of 07:09, 7 February 2018

Crystal Structure of Weissella viridescens FemX at 1.7 Ang Resolution

Structural highlights

1ne9 is a 1 chain structure with sequence from Atcc 12706. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:	femx (ATCC 12706)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Members of the FemABX protein family are novel therapeutic targets, as they are involved in the synthesis of the bacterial cell wall. They catalyze the addition of amino acid(s) on the peptidoglycan precursor using aminoacylated tRNA as a substrate. We report here the high-resolution structure of Weissella viridescens L-alanine transferase FemX and its complex with the UDP-MurNAc-pentapeptide. This is the first structure example of a FemABX family member that does not possess a coiled-coil domain. FemX consists of two structurally equivalent domains, separated by a cleft containing the binding site of the UDP-MurNAc-pentapeptide and a long channel that traverses one of the two domains. Our structural studies bring new insights into the evolution of the FemABX and the related GNAT superfamilies, shed light on the recognition site of the aminoacylated tRNA in Fem proteins, and allowed manual docking of the acceptor end of the alanyl-tRNAAla.

Crystal structures of Weissella viridescens FemX and its complex with UDP-MurNAc-pentapeptide: insights into FemABX family substrates recognition.,Biarrotte-Sorin S, Maillard AP, Delettre J, Sougakoff W, Arthur M, Mayer C Structure. 2004 Feb;12(2):257-67. PMID:14962386^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Biarrotte-Sorin S, Maillard AP, Delettre J, Sougakoff W, Arthur M, Mayer C. Crystal structures of Weissella viridescens FemX and its complex with UDP-MurNAc-pentapeptide: insights into FemABX family substrates recognition. Structure. 2004 Feb;12(2):257-67. PMID:14962386 doi:10.1016/j.str.2004.01.006

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ne9"

@@ Line 1: / Line 1: @@
 ==Crystal Structure of Weissella viridescens FemX at 1.7 Ang Resolution==
 <StructureSection load='1ne9' size='340' side='right' caption='[[1ne9]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1ne9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"lactobacillus_viridescens_subsp._minor"_kandler_and_albo-elnaga_1966 "lactobacillus viridescens subsp. minor" kandler and albo-elnaga 1966]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NE9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NE9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1ne9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_12706 Atcc 12706]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NE9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NE9 FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">femx ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1629 "Lactobacillus viridescens subsp. minor" Kandler and Albo-Elnaga 1966])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">femx ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1629 ATCC 12706])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ne9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ne9 OCA], [http://pdbe.org/1ne9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ne9 RCSB], [http://www.ebi.ac.uk/pdbsum/1ne9 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ne9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ne9 OCA], [http://pdbe.org/1ne9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ne9 RCSB], [http://www.ebi.ac.uk/pdbsum/1ne9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ne9 ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==
@@ Line 11: / Line 12: @@
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ne/1ne9_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ne/1ne9_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 30: / Line 31: @@
 __TOC__
 </StructureSection>
-[[Category: Lactobacillus viridescens subsp. minor kandler and albo-elnaga 1966]]
+[[Category: Atcc 12706]]
 [[Category: Arthur, M]]
 [[Category: Biarrotte-Sorin, S]]

1ne9

From Proteopedia

Revision as of 07:09, 7 February 2018

Crystal Structure of Weissella viridescens FemX at 1.7 Ang Resolution

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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