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This is a page on COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT.

Organism of Origin

African Clawed Frog

This frog can swim really fast in all directions. It is legal to own this frog in Canada and Ohio. In some other states, such as Arizona, California, and Hawaii, one needs a permit to own, transport, or sell these frogs. Unfortunately, this frog is commonly infected by parasites. The African Clawed Frog is the only amphibian that uses claws to climb and shred food.

Structure

COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT is a nucleosome.

There are a total of 418 which make up different histone structures on the inside.

The is found on the outside. The DNA chains are 146 nucleotides long.

There are also 6 manganese (II) ion in this protein.

Fun fact: The DNA in this protein is palindromic.

Function

This protein is involved in DNA binding, transcription, and initiation.

Significance

This protein is significant because it is a nucleosome, allowing DNA to be put into higher order structures. With this complex, DNA can be stored in a highly compact manner. DNA coils around the histones, and then the nucleosomes coil around to form the chromatosome, which then fold up on each other to form a chromosome.

References

Discussion 1-3.docx

https://en.wikipedia.org/wiki/African_clawed_frog

http://www.ebi.ac.uk/pdbe/entry/pdb/1aoi

https://www.nature.com/scitable/topicpage/dna-packaging-nucleosomes-and-chromatin-310