5nmz
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==human Neurturin (97-197)== | |
| - | + | <StructureSection load='5nmz' size='340' side='right' caption='[[5nmz]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5nmz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NMZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NMZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nmz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nmz OCA], [http://pdbe.org/5nmz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nmz RCSB], [http://www.ebi.ac.uk/pdbsum/5nmz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nmz ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/NRTN_HUMAN NRTN_HUMAN]] Hirschsprung disease. Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.<ref>PMID:9700200</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NRTN_HUMAN NRTN_HUMAN]] Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bigalke, J M]] | ||
| + | [[Category: Roth, R]] | ||
| + | [[Category: Sandmark, J]] | ||
| + | [[Category: Cystine knot]] | ||
| + | [[Category: Gfl]] | ||
| + | [[Category: Neurotrophic factor]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 06:24, 15 February 2018
human Neurturin (97-197)
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