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5nsd
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Co-crystal structure of NAMPT dimer with KPT-9274== | |
| - | + | <StructureSection load='5nsd' size='340' side='right' caption='[[5nsd]], [[Resolution|resolution]] 2.05Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5nsd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NSD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NSD FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=96Q:(~{E})-3-(6-azanylpyridin-3-yl)-~{N}-[[5-[4-[4,4-bis(fluoranyl)piperidin-1-yl]carbonylphenyl]-7-(4-fluorophenyl)-1-benzofuran-2-yl]methyl]prop-2-enamide'>96Q</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_phosphoribosyltransferase Nicotinamide phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.12 2.4.2.12] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nsd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nsd OCA], [http://pdbe.org/5nsd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nsd RCSB], [http://www.ebi.ac.uk/pdbsum/5nsd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nsd ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Nicotinamide phosphoribosyltransferase]] | ||
| + | [[Category: Baloglu, E]] | ||
| + | [[Category: Daelemans, D]] | ||
| + | [[Category: Dierckx, T]] | ||
| + | [[Category: Jacquemyn, M]] | ||
| + | [[Category: Kwanten, B]] | ||
| + | [[Category: Neggers, J E]] | ||
| + | [[Category: Noguchi, H]] | ||
[[Category: Senapedis, W]] | [[Category: Senapedis, W]] | ||
| - | [[Category: Noguchi, H]] | ||
| - | [[Category: Kwanten, B]] | ||
[[Category: Vercruysse, T]] | [[Category: Vercruysse, T]] | ||
[[Category: Voet, A]] | [[Category: Voet, A]] | ||
| - | [[Category: | + | [[Category: Crispr/ca]] |
| - | [[Category: | + | [[Category: Drug target]] |
| - | [[Category: | + | [[Category: Nampt]] |
| - | [[Category: | + | [[Category: Transferase]] |
| - | + | ||
Revision as of 06:24, 15 February 2018
Co-crystal structure of NAMPT dimer with KPT-9274
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