5uqu
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of mutant 2-methylcitrate synthase (mcsAG352A) from Aspergillus fumigatus== | |
| - | + | <StructureSection load='5uqu' size='340' side='right' caption='[[5uqu]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5uqu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UQU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UQU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5uqo|5uqo]], [[5uqq|5uqq]], [[5uqr|5uqr]], [[5uqs|5uqs]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uqu OCA], [http://pdbe.org/5uqu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uqu RCSB], [http://www.ebi.ac.uk/pdbsum/5uqu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uqu ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PRPC_ASPFM PRPC_ASPFM]] Component of the methylcitrate cycle that catalyzes the synthesis of (2S,3S)-2-methylcitrate from propionyl-CoA and oxaloacetate. Plays an important role in detoxification of propionyl-CoA, an inhibitor of both primary and secondary metabolism. Has also citrate synthase activity using as substrates acetyl-CoA and oxaloacetate. May play a role in virulence.<ref>PMID:16008561</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Chruszcz, M]] | [[Category: Chruszcz, M]] | ||
[[Category: Schlachter, C]] | [[Category: Schlachter, C]] | ||
| + | [[Category: 2-methylcitrate synthase]] | ||
| + | [[Category: Aspergillus fumigatus]] | ||
| + | [[Category: Citrate synthase]] | ||
| + | [[Category: Mcsa]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 06:27, 15 February 2018
Crystal structure of mutant 2-methylcitrate synthase (mcsAG352A) from Aspergillus fumigatus
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