5vyk

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'''Unreleased structure'''
 
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The entry 5vyk is ON HOLD until Paper Publication
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==Crystal structure of the BRS domain of BRAF in complex with the CC-SAM domain of KSR1==
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<StructureSection load='5vyk' size='340' side='right' caption='[[5vyk]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5vyk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VYK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VYK FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vyk OCA], [http://pdbe.org/5vyk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vyk RCSB], [http://www.ebi.ac.uk/pdbsum/5vyk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vyk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/KSR1_HUMAN KSR1_HUMAN]] Scaffolding protein that is part of a multiprotein signaling complex. Promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does not have kinase activity by itself.[UniProtKB:Q61097]
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__TOC__
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</StructureSection>
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Jin, T]]
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[[Category: Kurinov, I]]
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[[Category: Lavoie, H]]
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[[Category: Maisonneuve, P]]
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[[Category: Marullo, S A]]
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[[Category: SIcheri, F]]
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[[Category: Sahmi, M]]
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[[Category: Therrien, M]]
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[[Category: Thevakumaran, N]]
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[[Category: Br]]
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[[Category: Braf]]
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[[Category: Cc-sam]]
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[[Category: Complex]]
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[[Category: Kinase]]
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[[Category: Ksr1]]
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[[Category: Pseudokinase]]
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[[Category: Signaling protein]]
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[[Category: Signaling]]

Revision as of 06:28, 15 February 2018

Crystal structure of the BRS domain of BRAF in complex with the CC-SAM domain of KSR1

5vyk, resolution 1.75Å

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