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6bgo
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Singly PafE-capped 20S CP in Mycobacterium tuberculosis== | |
| - | + | <StructureSection load='6bgo' size='340' side='right' caption='[[6bgo]], [[Resolution|resolution]] 4.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6bgo]] is a 35 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BGO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BGO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proteasome_endopeptidase_complex Proteasome endopeptidase complex], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.25.1 3.4.25.1] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bgo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bgo OCA], [http://pdbe.org/6bgo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bgo RCSB], [http://www.ebi.ac.uk/pdbsum/6bgo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bgo ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PSA_MYCTA PSA_MYCTA]] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. [[http://www.uniprot.org/uniprot/BPA_MYCTO BPA_MYCTO]] Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction. Can inhibit degradation of Pup-tagged substrates in vitro by competing with Mpa for association with the proteasome.[UniProtKB:P9WKX3] [[http://www.uniprot.org/uniprot/PSB_MYCTA PSB_MYCTA]] Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Proteasome endopeptidase complex]] | ||
| + | [[Category: Hu, K]] | ||
[[Category: Li, H]] | [[Category: Li, H]] | ||
| - | [[Category: | + | [[Category: Hydrolase]] |
| + | [[Category: Protein degradation]] | ||
Revision as of 06:33, 15 February 2018
Singly PafE-capped 20S CP in Mycobacterium tuberculosis
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