6bsp
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==High-Resolution Structure Analysis of Antibody V5 and U4 Conformational Epitope on Human Papillomavirus 16== | |
| - | + | <StructureSection load='6bsp' size='340' side='right' caption='[[6bsp]], [[Resolution|resolution]] 4.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6bsp]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_16 Human papillomavirus type 16] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BSP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BSP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bsp OCA], [http://pdbe.org/6bsp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bsp RCSB], [http://www.ebi.ac.uk/pdbsum/6bsp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bsp ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/VL1_HPV16 VL1_HPV16]] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[HAMAP-Rule:MF_04002]<ref>PMID:12610160</ref> <ref>PMID:26289843</ref> <ref>PMID:8553535</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human papillomavirus type 16]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Ashley, R E]] | ||
| + | [[Category: Brendle, S A]] | ||
| + | [[Category: Bywaters, S M]] | ||
| + | [[Category: Christenson, N D]] | ||
| + | [[Category: Conway, J F]] | ||
[[Category: Guan, J]] | [[Category: Guan, J]] | ||
| - | [[Category: Christenson, N.D]] | ||
| - | [[Category: Brendle, S.A]] | ||
| - | [[Category: Bywaters, S.M]] | ||
| - | [[Category: Ashley, R.E]] | ||
| - | [[Category: Conway, J.F]] | ||
| - | [[Category: Makhov, A.M]] | ||
[[Category: Hafenstein, S]] | [[Category: Hafenstein, S]] | ||
| + | [[Category: Makhov, A M]] | ||
| + | [[Category: Fab]] | ||
| + | [[Category: H16 v5]] | ||
| + | [[Category: Hpv16]] | ||
| + | [[Category: Virus-immune system complex]] | ||
Revision as of 06:34, 15 February 2018
High-Resolution Structure Analysis of Antibody V5 and U4 Conformational Epitope on Human Papillomavirus 16
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