5vkv
From Proteopedia
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<StructureSection load='5vkv' size='340' side='right' caption='[[5vkv]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | <StructureSection load='5vkv' size='340' side='right' caption='[[5vkv]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5vkv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VKV FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5vkv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thet8 Thet8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VKV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VKV FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vkv OCA], [http://pdbe.org/5vkv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vkv RCSB], [http://www.ebi.ac.uk/pdbsum/5vkv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vkv ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TTHA1409 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=300852 THET8])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vkv OCA], [http://pdbe.org/5vkv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vkv RCSB], [http://www.ebi.ac.uk/pdbsum/5vkv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vkv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Membrane oxidoreductase CcdA plays a central role in supplying reducing equivalents from the bacterial cytoplasm to the envelope. It transports electrons across the membrane using a single pair of cysteines by a mechanism that has not yet been elucidated. Here we report an NMR structure of the Thermus thermophilus CcdA (TtCcdA) in an oxidized and outward-facing state. CcdA consists of two inverted structural repeats of three transmembrane helices (2 x 3-TM). We computationally modeled and experimentally validated an inward-facing state, which suggests that CcdA uses an elevator-type movement to shuttle the reactive cysteines across the membrane. CcdA belongs to the LysE superfamily, and thus its structure may be relevant to other LysE clan transporters. Structure comparisons of CcdA, semiSWEET, Pnu, and major facilitator superfamily (MFS) transporters provide insights into membrane transporter architecture and mechanism. | ||
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| + | Solution structure and elevator mechanism of the membrane electron transporter CcdA.,Zhou Y, Bushweller JH Nat Struct Mol Biol. 2018 Feb;25(2):163-169. doi: 10.1038/s41594-018-0022-z. Epub, 2018 Jan 29. PMID:29379172<ref>PMID:29379172</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5vkv" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Thet8]] | ||
[[Category: Bushweller, J H]] | [[Category: Bushweller, J H]] | ||
[[Category: Zhou, Y]] | [[Category: Zhou, Y]] | ||
Revision as of 07:00, 15 February 2018
Solution NMR structure of the membrane electron transporter CcdA
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