Sandbox Reserved 1321

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2r7e is a cool protein.
2r7e is a cool protein.
== Structural highlights ==
== Structural highlights ==
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2r7e is a 2 chain structure found in humans. It has 5 associated ligands ( <scene name='77/777641/Ca/3'>CA</scene>, <scene name='77/777641/Cu/1'>CU</scene>, BMA, MAN, NAG) and is coded for by 2 different genes, F8 and F8C. 2r7e has bot<scene name='77/777641/Alpha_helix/1'>Alpha Helix</scene> and beta pleated sheet secondary structure. Alterations in this structure can lead to improper location of ligands, leading to failed protein function.
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2r7e is a 2 chain structure found in humans. It has 5 associated ligands ( <scene name='77/777641/Ca/3'>CA</scene>, <scene name='77/777641/Cu/1'>CU</scene>, BMA, MAN, NAG) and is coded for by 2 different genes, F8 and F8C. 2r7e has both <scene name='77/777641/Alpha_helix/1'>Alpha Helix</scene> and </StructureSection><scene name='77/777641/Beta_pleated_sheet/1'>Beta Pleated Sheet</scene> secondary structure. Alterations in this structure can lead to improper location of ligands, leading to failed protein function.
== Ligands ==
== Ligands ==
2r7e has 5 ligands, which are binding sites for other proteins in Coagulation Factor VIII
2r7e has 5 ligands, which are binding sites for other proteins in Coagulation Factor VIII
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Mutations in 2r7e can alter the structure of Coagulation Factor VIII, leading to hemophilia a.
Mutations in 2r7e can alter the structure of Coagulation Factor VIII, leading to hemophilia a.
== Relevance ==
== Relevance ==
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Yay!
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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</StructureSection>
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== References ==
== References ==
h http://www.uniprot.org/uniprot/P00451
h http://www.uniprot.org/uniprot/P00451

Revision as of 21:00, 20 February 2018

This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Contents

2r7e Overview

2r7e 3-D Structure

Drag the structure with the mouse to rotate
secondary structure. Alterations in this structure can lead to improper location of ligands, leading to failed protein function.

Ligands

2r7e has 5 ligands, which are binding sites for other proteins in Coagulation Factor VIII

Function

2r7e is a protein that makes up part of Coagulation Factor VIII, which is a protein complex involved in blood clotting in humans. Coagulation Factor VIII works with calcium and phosholipids to Factor X to its activated form Xa.

Disease

Mutations in 2r7e can alter the structure of Coagulation Factor VIII, leading to hemophilia a.

Relevance

Yay!

References

h http://www.uniprot.org/uniprot/P00451

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