Sandbox Reserved 1321
From Proteopedia
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2r7e is a cool protein. | 2r7e is a cool protein. | ||
== Structural highlights == | == Structural highlights == | ||
| - | 2r7e is a 2 chain structure found in humans. It has 5 associated ligands | + | 2r7e is a 2 chain structure found in humans. It has 5 associated ligands and is coded for by 2 different genes, F8 and F8C. 2r7e has both <scene name='77/777641/Alpha_helix/1'>Alpha Helix</scene> and <scene name='77/777641/Beta_pleated_sheet/1'>Beta Pleated Sheet</scene> secondary structure. Alterations in this structure can lead to improper location of ligands, leading to failed protein function. Also, most proteins including 2r7e, incorporate other macromolecules in order to create a stronger structure. In this case, 2r7e relies on <scene name='77/777641/Carbohydrates/1'>Carbohydrates</scene> to hold the structure together. |
== Ligands == | == Ligands == | ||
| - | 2r7e has 5 ligands, which are binding sites for other proteins in Coagulation Factor VIII | + | 2r7e has 5 ligands (<scene name='77/777641/Ca/3'>CA</scene>, <scene name='77/777641/Cu/1'>CU</scene>, BMA, MAN, NAG), which are binding sites for other proteins in Coagulation Factor VIII. |
== Function == | == Function == | ||
2r7e is a protein that makes up part of Coagulation Factor VIII, which is a protein complex involved in blood clotting in humans. Coagulation Factor VIII works with calcium and phosholipids to Factor X to its activated form Xa. | 2r7e is a protein that makes up part of Coagulation Factor VIII, which is a protein complex involved in blood clotting in humans. Coagulation Factor VIII works with calcium and phosholipids to Factor X to its activated form Xa. | ||
Revision as of 21:06, 20 February 2018
| This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430. |
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2r7e Overview
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