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Sandbox Reserved 1311
From Proteopedia
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==Human C-Reactive protein== | ==Human C-Reactive protein== | ||
===Function=== | ===Function=== | ||
| - | + | Human C-reactive protein is a member of the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli."<ref>https://www.ncbi.nlm.nih.gov/gene/1401</ref> | |
==Phosphocholine== | ==Phosphocholine== | ||
| - | + | Phosphocholine serves a binding target for C-reactive protein. | |
===Function=== | ===Function=== | ||
General Function: Low-density lipoprotein particle receptor binding | General Function: Low-density lipoprotein particle receptor binding | ||
| - | Specific Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. | + | Specific Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.<ref>https://pubchem.ncbi.nlm.nih.gov/compound/phosphocholine</ref> |
| - | == | + | ===Properties===<ref>https://pubchem.ncbi.nlm.nih.gov/compound/phosphocholine</ref> |
| + | Molecular Weight: 184.152 g/mol | ||
| + | Biofluid Locations: blood, breast milk, cerebrospinal fluid, saliva, urine | ||
| + | Tissue Locations: Brain, Epidermis, Fibroblasts, Intestine, Kidney, Liver, Placenta, Platelet, Stratum Corneum | ||
| + | Cellular location: cytoplasm, exosomes | ||
| + | Target: CRP | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 21:13, 20 February 2018
| This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430. |
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HUMAN C-REACTIVE PROTEIN COMPLEXED WITH PHOSPHOCHOLINE
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