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Sandbox Reserved 1326

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Protein binding:Selectively binds to other protein complexes non-covalently. 1a4y also works to inhibit ANG in order to inhibit angiogenesis, along with RNASE1 to inhibit an endonuclease that cleaves phosphodiester bonds, and RNASE2 .
Protein binding:Selectively binds to other protein complexes non-covalently. 1a4y also works to inhibit ANG in order to inhibit angiogenesis, along with RNASE1 to inhibit an endonuclease that cleaves phosphodiester bonds, and RNASE2 .
== Disease ==
== Disease ==
-
<scene name='77/777646/Angiogenin/1'>Ang</scene> <scene name='77/777646/Angiogenin/1'>Text To Be Displayed</scene>has a role in cancers and tumor growth. A mutation in 1a4y which results in decreased activity and thus increased activity of Ang could lead to tumor growth. Ang has also been theorized as a protector of the central nervous system and thus over-production of 1a4y may result in limited Ang and thus neurodegenerative diseases.
+
<scene name='77/777646/Angiogenin/1'>Ang</scene> has a role in cancers and tumor growth. A mutation in 1a4y which results in decreased activity and thus increased activity of Ang could lead to tumor growth. Ang has also been theorized as a protector of the central nervous system and thus over-production of 1a4y may result in limited Ang and thus neurodegenerative diseases.
== Relevance ==
== Relevance ==

Revision as of 21:50, 20 February 2018

This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Structure of la4y

Ribonuclease Inhibitor-Angiogenin Complex

Drag the structure with the mouse to rotate


</StructureSection>

References

  1. ↑ Papageorgiou AC, Shapiro R, Acharya KR. Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution. EMBO J. 1997 Sep 1;16(17):5162-77. PMID:9311977 doi:10.1093/emboj/16.17.5162
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

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