Sandbox Reserved 1353
From Proteopedia
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==Structure== | ==Structure== | ||
<StructureSection load='1xmi' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1xmi' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| + | Composed of 1480 amino acids in 5 domains, each connected by a nucleotide binding domain. | ||
== Function == | == Function == | ||
The protein regulates transport of bicarbonate and chloride ions. | The protein regulates transport of bicarbonate and chloride ions. | ||
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The protein is crucial for ion circulation in epithelial cells, with lack of function leading to serious disease. | The protein is crucial for ion circulation in epithelial cells, with lack of function leading to serious disease. | ||
== Structural highlights == | == Structural highlights == | ||
| - | The nbd1 domain is altered in CF patients, due to deletion of residue Phe-508 which results in a severe loss of function. | + | The nbd1 domain is altered in CF patients, due to deletion of residue Phe-508 which results in a severe loss of function. |
| + | Mutation at any of the below sites confers resistance to salmonella to the cell. | ||
| + | These mutations also prevent diarrhea from Cholera in mice. | ||
<scene name='77/777673/F508_sites/1'>F508 Mutation Site Nucleotide Binding</scene> | <scene name='77/777673/F508_sites/1'>F508 Mutation Site Nucleotide Binding</scene> | ||
Revision as of 20:59, 21 February 2018
| This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430. |
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Structure
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References
protein
