5y9j

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m (Protected "5y9j" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5y9j is ON HOLD until Paper Publication
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==BAFF in complex with belimumab==
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<StructureSection load='5y9j' size='340' side='right' caption='[[5y9j]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5y9j]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y9J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y9J FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y9j OCA], [http://pdbe.org/5y9j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y9j RCSB], [http://www.ebi.ac.uk/pdbsum/5y9j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y9j ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TN13B_HUMAN TN13B_HUMAN]] Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.<ref>PMID:10973284</ref> Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity).<ref>PMID:10973284</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Heo, Y S]]
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[[Category: Shin, W]]
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[[Category: Antibody]]
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[[Category: Baff]]
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[[Category: Belimumab]]
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[[Category: Lupus]]
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[[Category: Protein binding]]

Revision as of 07:20, 22 February 2018

BAFF in complex with belimumab

5y9j, resolution 2.05Å

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