6bw6
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Human GPT (DPAGT1) H129 variant in complex with tunicamycin== | |
| - | + | <StructureSection load='6bw6' size='340' side='right' caption='[[6bw6]], [[Resolution|resolution]] 2.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6bw6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BW6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene>, <scene name='pdbligand=TUM:TUNICAMYCIN'>TUM</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylglucosamine--dolichyl-phosphate_N-acetylglucosaminephosphotransferase UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.8.15 2.7.8.15] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bw6 OCA], [http://pdbe.org/6bw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bw6 RCSB], [http://www.ebi.ac.uk/pdbsum/6bw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bw6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/GPT_HUMAN GPT_HUMAN]] DPAGT1-CDG;Congenital myasthenic syndromes with glycosylation defect. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GPT_HUMAN GPT_HUMAN]] Catalyzes the initial step in the synthesis of dolichol-P-P-oligosaccharides. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase]] | ||
| + | [[Category: Kuk, A C.Y]] | ||
| + | [[Category: Lee, S Y]] | ||
| + | [[Category: Mashalidis, E H]] | ||
| + | [[Category: Yoo, J]] | ||
| + | [[Category: Endoplasmic reticulum]] | ||
| + | [[Category: N-linked glycosylation]] | ||
| + | [[Category: Natural product]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Transferase-antibiotic complex]] | ||
| + | [[Category: Tunicamycin]] | ||
Revision as of 07:28, 22 February 2018
Human GPT (DPAGT1) H129 variant in complex with tunicamycin
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