5uot

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'''Unreleased structure'''
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{{Large structure}}
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==CryoEM structure of the helical assembly of full length MxB==
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The entry 5uot is ON HOLD until Paper Publication
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<StructureSection load='5uot' size='340' side='right' caption='[[5uot]], [[Resolution|resolution]] 4.60&Aring;' scene=''>
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== Structural highlights ==
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Authors:
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<table><tr><td colspan='2'>[[5uot]] is a 62 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UOT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UOT FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uot OCA], [http://pdbe.org/5uot PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uot RCSB], [http://www.ebi.ac.uk/pdbsum/5uot PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uot ProSAT]</span></td></tr>
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Description:
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</table>
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[[Category: Unreleased Structures]]
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{{Large structure}}
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== Function ==
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[[http://www.uniprot.org/uniprot/MX2_HUMAN MX2_HUMAN]] Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.<ref>PMID:15184662</ref> <ref>PMID:24048477</ref> <ref>PMID:24055605</ref> <ref>PMID:24121441</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Alvarez, F J.D]]
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[[Category: Perilla, J R]]
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[[Category: Schulten, K]]
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[[Category: Zhang, P]]
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[[Category: Antiviral protein]]
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[[Category: Assembly]]
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[[Category: Cryoem]]
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[[Category: Dynamin]]
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[[Category: Helical reconstruction]]
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[[Category: Hiv-1]]
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[[Category: Interferon]]
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[[Category: Molecular dynamic simulation]]
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[[Category: Mx2]]
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[[Category: Mxb]]

Revision as of 07:32, 22 February 2018

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CryoEM structure of the helical assembly of full length MxB

5uot, resolution 4.60Å

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OCA

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