6c8r
From Proteopedia
(Difference between revisions)
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<StructureSection load='6c8r' size='340' side='right' caption='[[6c8r]], [[Resolution|resolution]] 1.95Å' scene=''> | <StructureSection load='6c8r' size='340' side='right' caption='[[6c8r]], [[Resolution|resolution]] 1.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6c8r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C8R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C8R FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6c8r]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Catro Catro]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6C8R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6C8R FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EQV:Loganic+acid'>EQV</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EQV:Loganic+acid'>EQV</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c8r OCA], [http://pdbe.org/6c8r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c8r RCSB], [http://www.ebi.ac.uk/pdbsum/6c8r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c8r ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6c8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6c8r OCA], [http://pdbe.org/6c8r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6c8r RCSB], [http://www.ebi.ac.uk/pdbsum/6c8r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6c8r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | : Loganin is an iridoid glycoside of interest as both an intermediate in the biosynthesis of indole alkaloids in plants and as a bioactive compound itself. The loganic acid methyltransferase catalyzes the methylation of a monoterpenoid glycoside precursor to produce loganin, and demonstrates stereospecificity for the (6S,7R) substrate. Here, we biochemically characterize this biocatalyst and elucidate the basis for its strict substrate specificity. These studies may help facilitate the design of new classes of monoterpenoid indole alkaloids of pharmaceutical interest. | ||
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| + | Loganic Acid Methyltransferase: Insights into the specificity of methylation on an iridoid glycoside.,Petronikolou N, Hollatz A, Schuler MA, Nair SK Chembiochem. 2018 Feb 5. doi: 10.1002/cbic.201700679. PMID:29399933<ref>PMID:29399933</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6c8r" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Catro]] | ||
[[Category: Nair, S K]] | [[Category: Nair, S K]] | ||
[[Category: Petronikolou, N]] | [[Category: Petronikolou, N]] | ||
Revision as of 08:28, 22 February 2018
Loganic acid O-methyltransferase complexed with SAH and loganic acid
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