Sandbox Reserved 1392
From Proteopedia
(Difference between revisions)
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{{Sandbox_Reserved_HLSC322}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_Reserved_HLSC322}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
| - | == | + | ==Human E-cadherin Protein== |
<StructureSection load='1bna' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1bna' size='340' side='right' caption='Caption for this structure' scene=''> | ||
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
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== Function == | == Function == | ||
| + | Epithelial-cadherin (1-213), or E-cadherin, is a calcium-dependent cell adhesion protein. E-cadherin help regulate bacterial interaction with mammalian tissues and play a key role in blastula formation. | ||
== Disease == | == Disease == | ||
| + | E-cadherin is a tumor suppressor gene. Degradation or loss of function of the gene is thought to be linked to metastasis and proliferation of tumors. In particular, mutations in the E-cadherin gene are linked to a series of cancers, including gastric, breast, colorectal, ovarian, and thyroid cancers. | ||
== Relevance == | == Relevance == | ||
== Structural highlights == | == Structural highlights == | ||
| - | + | E-cadherin is 213 amino acids long. The molecule is comprised of five cadherin extensions, a transmembrane region, and a cytoplasmic tail. In epithelial cells, E-cadherin contains cell-to-cell junctions often located close to actin-filaments within the cytoskeleton of a cell. E-cadherin is a homodimer, meaning that it is made up of two identical subunits. | |
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
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</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
| - | + | https://www.ebi.ac.uk/pdbe/entry/pdb/2o72/ | |
| + | http://www.uniprot.org/uniprot/P12830 | ||
| + | https://en.wikipedia.org/wiki/CDH1_(gene) | ||
Revision as of 21:41, 22 February 2018
| This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430. |
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Human E-cadherin Protein
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References
https://www.ebi.ac.uk/pdbe/entry/pdb/2o72/ http://www.uniprot.org/uniprot/P12830 https://en.wikipedia.org/wiki/CDH1_(gene)
