2ewa

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|SITE=
|SITE=
|LIGAND= <scene name='pdbligand=SB2:4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE'>SB2</scene>
|LIGAND= <scene name='pdbligand=SB2:4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE'>SB2</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1]
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
|GENE= Mapk14, Crk1, Csbp1, Csbp2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
|GENE= Mapk14, Crk1, Csbp1, Csbp2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ewa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ewa OCA], [http://www.ebi.ac.uk/pdbsum/2ewa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ewa RCSB]</span>
}}
}}
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[[Category: Michot, N.]]
[[Category: Michot, N.]]
[[Category: Pouzieux, S.]]
[[Category: Pouzieux, S.]]
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[[Category: SB2]]
 
[[Category: dfg out]]
[[Category: dfg out]]
[[Category: map kinase]]
[[Category: map kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:45:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:54:38 2008''

Revision as of 23:54, 30 March 2008


PDB ID 2ewa

Drag the structure with the mouse to rotate
, resolution 2.1Å
Ligands:
Gene: Mapk14, Crk1, Csbp1, Csbp2 (Mus musculus)
Activity: Non-specific serine/threonine protein kinase, with EC number 2.7.11.1
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Dual binding mode of pyridinylimidazole to MAP kinase p38


About this Structure

2EWA is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

NMR characterization of kinase p38 dynamics in free and ligand-bound forms., Vogtherr M, Saxena K, Hoelder S, Grimme S, Betz M, Schieborr U, Pescatore B, Robin M, Delarbre L, Langer T, Wendt KU, Schwalbe H, Angew Chem Int Ed Engl. 2006 Jan 30;45(6):993-7. PMID:16374788

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