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<Structure load='1f88' size='350' frame='true' align='right' caption='Retinal is in red, and scotopsin is in blue' scene='Insert optional ' /> | <Structure load='1f88' size='350' frame='true' align='right' caption='Retinal is in red, and scotopsin is in blue' scene='Insert optional ' /> | ||
| - | <scene name='77/777643/Retinal_and_scotopsin/ | + | <scene name='77/777643/Retinal_and_scotopsin/2'>Retinal and Scotopsin</scene> |
| - | + | ||
| - | == | + | == Function == |
| - | === | + | Rhodopsin is a biological pigment found in the rods of the retina and is a G-protein-coupled receptor (GPCR). Rhodopsin is extremely sensitive to light, and thus enables vision in low-light conditions. However, when rhodospin is exposed to light it automatically photobleaches and vision will be inhibited. In humans, it usually regenerates after about 30 minutes. Rhodopsin of the rods most strongly absorbs green-blue light and, therefore, appears reddish-purple, which is why it is also called "visual purple". It is responsible for monochromatic vision in the dark. |
| - | + | ==Your Heading Here (maybe something like 'Structure')== | |
| - | === | + | <StructureSection load='3rec' size='350' side='right' caption='Escherichia coli reca protein-bound DNA (PDB entry [[3rec]])' scene=''> |
| + | == Disease == | ||
| + | == Relevance == | ||
| + | </StructureSection> | ||
| + | == Structural highlights == | ||
| + | Retinal is produced in the retina from vitamin A, from dietary beta-carotene. When rhodopsin absorbs light, its retinal cofactor isomerizes from the 11-cis to the all-trans configuration. | ||
| + | Lysine 296: In rhodopsin, the aldehyde group of retinal is covalently linked to the amino group of a lysine residue on the protein in a protonated Schiff base (-NH+=CH-) when it ligands to a metal atom. | ||
== References == | == References == | ||
<references/> | <references/> | ||
| - | [1] https://www.ebi.ac.uk/pdbe/entry/pdb/1f88 | ||
| - | [2] https://www.rcsb.org/structure/1f88 | ||
| - | [3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560097/ | ||
Revision as of 23:19, 25 February 2018
Contents |
Bovine Rhodopsin
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Function
Rhodopsin is a biological pigment found in the rods of the retina and is a G-protein-coupled receptor (GPCR). Rhodopsin is extremely sensitive to light, and thus enables vision in low-light conditions. However, when rhodospin is exposed to light it automatically photobleaches and vision will be inhibited. In humans, it usually regenerates after about 30 minutes. Rhodopsin of the rods most strongly absorbs green-blue light and, therefore, appears reddish-purple, which is why it is also called "visual purple". It is responsible for monochromatic vision in the dark.
Your Heading Here (maybe something like 'Structure')
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Structural highlights
Retinal is produced in the retina from vitamin A, from dietary beta-carotene. When rhodopsin absorbs light, its retinal cofactor isomerizes from the 11-cis to the all-trans configuration. Lysine 296: In rhodopsin, the aldehyde group of retinal is covalently linked to the amino group of a lysine residue on the protein in a protonated Schiff base (-NH+=CH-) when it ligands to a metal atom.
