Sandbox Reserved 1410
From Proteopedia
| Line 1: | Line 1: | ||
==COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT== | ==COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT== | ||
| - | <Structure load='1aoi' size=' | + | <Structure load='1aoi' size='500' frame='true' align='right' caption='Structure of COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT' scene='' /> |
| - | + | COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT is a histone complex. | |
| - | + | ||
== Organism of Origin == | == Organism of Origin == | ||
| - | This protein comes form the African Clawed Frog (''Xenopus Laevis''). [[Image:1200px- | + | This protein comes form the African Clawed Frog (''Xenopus Laevis''). [[Image:1200px-Xenopus_laevsis_02.jpg | thumb | left | African Clawed Frog]] |
| + | |||
This frog can swim really fast in all directions. | This frog can swim really fast in all directions. | ||
| + | |||
It is legal to own this frog in Canada and Ohio. In some other states, such as Arizona, California, and Hawaii, one needs a permit to own, transport, or sell these frogs. | It is legal to own this frog in Canada and Ohio. In some other states, such as Arizona, California, and Hawaii, one needs a permit to own, transport, or sell these frogs. | ||
| + | |||
Unfortunately, this frog is commonly infected by parasites. | Unfortunately, this frog is commonly infected by parasites. | ||
| - | The African Clawed Frog is the only amphibian that uses claws to climb and shred food. | + | |
| + | Fun fact: The African Clawed Frog is the only amphibian that uses claws to climb and shred food. | ||
== Structure == | == Structure == | ||
COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT is a nucleosome. | COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT is a nucleosome. | ||
| - | There are a total of 418 <scene name='77/777730/1aoi_not_dna/2'>amino acids</scene> which make up different histone structures on the inside. | + | There are a total of 418 <scene name='77/777730/1aoi_not_dna/2'>amino acids</scene> which make up four different histone structures on the inside (Histone H3.3C, H4, H2A type 1, and H2B 1.1). |
The <scene name='77/777730/1aoi_dna_only/1'>DNA</scene> is found on the outside. The DNA chains are 146 nucleotides long. | The <scene name='77/777730/1aoi_dna_only/1'>DNA</scene> is found on the outside. The DNA chains are 146 nucleotides long. | ||
| Line 29: | Line 32: | ||
== References == | == References == | ||
| - | Discussion 1-3.docx | ||
| - | |||
https://en.wikipedia.org/wiki/African_clawed_frog | https://en.wikipedia.org/wiki/African_clawed_frog | ||
Revision as of 16:36, 26 February 2018
Contents |
COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT
|
COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT is a histone complex.
Organism of Origin
This protein comes form the African Clawed Frog (Xenopus Laevis).This frog can swim really fast in all directions.
It is legal to own this frog in Canada and Ohio. In some other states, such as Arizona, California, and Hawaii, one needs a permit to own, transport, or sell these frogs.
Unfortunately, this frog is commonly infected by parasites.
Fun fact: The African Clawed Frog is the only amphibian that uses claws to climb and shred food.
Structure
COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT is a nucleosome.
There are a total of 418 which make up four different histone structures on the inside (Histone H3.3C, H4, H2A type 1, and H2B 1.1).
The is found on the outside. The DNA chains are 146 nucleotides long.
There are also 6 manganese (II) ion in this protein.
Fun fact: The DNA in this protein is palindromic.
Function
This protein is involved in DNA binding, transcription, and initiation.
Significance
This protein is significant because it is a nucleosome, allowing DNA to be put into higher order structures. With this complex, DNA can be stored in a highly compact manner. DNA coils around the histones, and then the nucleosomes coil around to form the chromatosome, which then fold up on each other to form a chromosome.
References
https://en.wikipedia.org/wiki/African_clawed_frog
http://www.ebi.ac.uk/pdbe/entry/pdb/1aoi
https://www.nature.com/scitable/topicpage/dna-packaging-nucleosomes-and-chromatin-310
