Sandbox Reserved 1410
From Proteopedia
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== Organism of Origin == | == Organism of Origin == | ||
| - | This protein comes form the African Clawed Frog (''Xenopus Laevis''). [[Image: | + | This protein comes form the African Clawed Frog (''Xenopus Laevis''). [[Image:Africanclawedfrog.jpg|thumb|left|African Clawed Frog]] |
This frog can swim really fast in all directions. | This frog can swim really fast in all directions. | ||
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COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT is a nucleosome. | COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT is a nucleosome. | ||
| - | There are a total of 418 <scene name='77/777730/1aoi_not_dna/2'>amino acids</scene> which make up four different histone structures on the inside (Histone H3.3C, H4, H2A type 1, and H2B 1.1). | + | There are a total of 418 <scene name='77/777730/1aoi_not_dna/2'>amino acids</scene> which make up four different histone structures on the inside (Histone H3.3C, H4, H2A type 1, and H2B 1.1). The N-terminus tails of H3 and H2B allow the histone complex to interact with other histone complexes. |
The <scene name='77/777730/1aoi_dna_only/1'>DNA</scene> is found on the outside. The DNA chains are 146 nucleotides long. | The <scene name='77/777730/1aoi_dna_only/1'>DNA</scene> is found on the outside. The DNA chains are 146 nucleotides long. | ||
| + | |||
| + | The hydrogen bond interactions between the histone structures and the DNA makes this molecule a histone complex. | ||
There are also 6 manganese (II) ion <scene name='77/777730/1aoi_ligands/1'>ligands</scene> in this protein. | There are also 6 manganese (II) ion <scene name='77/777730/1aoi_ligands/1'>ligands</scene> in this protein. | ||
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== Function == | == Function == | ||
| - | This protein is involved in DNA binding | + | This protein is involved in DNA packaging, binding, and transcription. |
== Significance == | == Significance == | ||
| - | This protein is significant because it is a nucleosome, allowing DNA to be put into higher order structures. With this complex, DNA can be stored in a highly compact manner. DNA coils around the histones, and then the nucleosomes coil around to form the chromatosome, which then fold up on each other to form a chromosome. | + | This protein is significant because it is a nucleosome, allowing DNA to be put into higher order structures. With this complex, DNA can be stored in a highly compact manner. DNA coils around the histones, and then the nucleosomes coil around to form the chromatosome, which then fold up on each other to form a chromosome. This resulting complex also prevents unwanted binding and transcription of DNA because it is so tightly wound together. |
== References == | == References == | ||
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https://www.nature.com/scitable/topicpage/dna-packaging-nucleosomes-and-chromatin-310 | https://www.nature.com/scitable/topicpage/dna-packaging-nucleosomes-and-chromatin-310 | ||
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| + | https://www.nature.com/articles/38444 | ||
Revision as of 16:48, 26 February 2018
Contents |
COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT
|
COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT is a histone complex.
Organism of Origin
This protein comes form the African Clawed Frog (Xenopus Laevis).
This frog can swim really fast in all directions.
It is legal to own this frog in Canada and Ohio. In some other states, such as Arizona, California, and Hawaii, one needs a permit to own, transport, or sell these frogs.
Unfortunately, this frog is commonly infected by parasites.
Fun fact: The African Clawed Frog is the only amphibian that uses claws to climb and shred food.
Structure
COMPLEX BETWEEN NUCLEOSOME CORE PARTICLE (H3,H4,H2A,H2B) AND 146 BP LONG DNA FRAGMENT is a nucleosome.
There are a total of 418 which make up four different histone structures on the inside (Histone H3.3C, H4, H2A type 1, and H2B 1.1). The N-terminus tails of H3 and H2B allow the histone complex to interact with other histone complexes.
The is found on the outside. The DNA chains are 146 nucleotides long.
The hydrogen bond interactions between the histone structures and the DNA makes this molecule a histone complex.
There are also 6 manganese (II) ion in this protein.
Fun fact: The DNA in this protein is palindromic.
Function
This protein is involved in DNA packaging, binding, and transcription.
Significance
This protein is significant because it is a nucleosome, allowing DNA to be put into higher order structures. With this complex, DNA can be stored in a highly compact manner. DNA coils around the histones, and then the nucleosomes coil around to form the chromatosome, which then fold up on each other to form a chromosome. This resulting complex also prevents unwanted binding and transcription of DNA because it is so tightly wound together.
References
https://en.wikipedia.org/wiki/African_clawed_frog
http://www.ebi.ac.uk/pdbe/entry/pdb/1aoi
https://www.nature.com/scitable/topicpage/dna-packaging-nucleosomes-and-chromatin-310
