Sandbox Reserved 1326

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 13: Line 13:
Mutations in Angiogenin can result in drastic impacts on human health. As stated above, over or under production/activity can result in a broad range of diseases from cancers to neurodegenerative disorders.
Mutations in Angiogenin can result in drastic impacts on human health. As stated above, over or under production/activity can result in a broad range of diseases from cancers to neurodegenerative disorders.
== Structural highlights ==
== Structural highlights ==
-
1a4y is the result of a complex of hRI and human Angiogenin.
+
<scene name='77/777646/Ribonuclease_inhibitor_1/1'>Ribonuclease Inhibitor</scene>-The unusual non-globular structure of ribonuclease inhibitor, its solvent parallel <scene name='77/777646/Beta-sheets/1'>Beta-sheet</scene> and the conformational flexibility of the structure are used in the interaction. These structures make the ribonuclease inhibitor an effective binding protein. Ribonuclease inhibitor is encoded by the gene RNH1.
-
<scene name='77/777646/Ribonuclease_inhibitor_1/1'>Ribonuclease Inhibitor</scene>-The unusual non-globular structure of ribonuclease inhibitor, its solvent parallel Beta-sheet and the conformational flexibility of the structure are used in the interaction. These structures make the ribonuclease inhibitor an effective binding protein. Ribonuclease inhibitor is encoded by the gene RNH1.
+
Angiogenin- Encoded for by the ANG gene. It makes up the b and e chains of the 1a4y protein. It goes from residue numbers 25 to 147.
Angiogenin- Encoded for by the ANG gene. It makes up the b and e chains of the 1a4y protein. It goes from residue numbers 25 to 147.

Revision as of 01:54, 27 February 2018

This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Structure of la4y(A Ribonuclease Inhibitor-Angiogenin Complex)

Ribonuclease Inhibitor-Angiogenin Complex

Drag the structure with the mouse to rotate


</StructureSection>

References

  1. ↑ Papageorgiou AC, Shapiro R, Acharya KR. Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution. EMBO J. 1997 Sep 1;16(17):5162-77. PMID:9311977 doi:10.1093/emboj/16.17.5162
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

[1] [2]

Retrieved from "http://52.214.119.220/wiki/index.php/Sandbox_Reserved_1326"
Personal tools