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The ribonuclease inhibitor-angiogenin complex is a protein found in human placental cells. The ribonuclease inhibitor protein and angiogenin protein have a strong affinity for each other. The main gene that codes for the ribonuclease inhibitor is RNH1. Ribonuclease also inhibits other proteins such as RNASE1 and RNASE2, so it is also important in processing RNA.

Function

The complex is responsible for protein binding and positive regulation of phosphorylation. The ribonuclease inhibitor protein binds to the angiogenin complex, a blood-vessel inducing protein, to inhibit it. Angiogenin is able to promote growth of blood vessels by promoting rRNA transcription.

Relevance

Angiogenin has been known to be involved in normal and tumor growth during angiogenesis. The presence of inhibitors, such as ribonuclease inhibitor, blocks angiogenin and limits blood vessel growth. This can therefore curb proliferation of cancer cells. Malfunctions in angiogenin are also a main cause of

Structural highlights

The complex consists of two distinct protein molecules: ribonuclease inhibitor and angiogenin. The ribonuclease inhibitor has two chains, . The angiogenin molecule consists of two chains, . The ribonuclease inhibitor molecule is particularly rich in repeats. Because the complex consists of the two molecules, there are sites of high interaction. The places of strongest contact are between the residue in angiogenin and in ribonuclease inhibitor.