Sandbox Reserved 1326

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Mutations in Angiogenin can result in drastic impacts on human health. As stated above, over or under production/activity can result in a broad range of diseases from cancers to neurodegenerative disorders.
Mutations in Angiogenin can result in drastic impacts on human health. As stated above, over or under production/activity can result in a broad range of diseases from cancers to neurodegenerative disorders.
== Structural highlights ==
== Structural highlights ==
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<scene name='77/777646/Ribonuclease_inhibitor_1/1'>Ribonuclease Inhibitor</scene>-The unusual non-globular structure of ribonuclease inhibitor, its solvent parallel <scene name='77/777646/Beta-sheets/1'>Beta-sheet</scene> and the conformational flexibility of the structure are used in the interaction. These structures make the ribonuclease inhibitor an effective binding protein. Ribonuclease inhibitor is encoded by the gene RNH1.
+
<scene name='77/777646/Ribonuclease_inhibitor_1/1'>Ribonuclease Inhibitor</scene>-The unusual non-globular structure of ribonuclease inhibitor, its solvent parallel <scene name='77/777646/Beta-strands/1'>Beta-sheet</scene> and the conformational flexibility of the structure are used in the interaction. These structures make the ribonuclease inhibitor an effective binding protein. Ribonuclease inhibitor is encoded by the gene RNH1.
Angiogenin- Encoded for by the ANG gene. It makes up the b and e chains of the 1a4y protein. It goes from residue numbers 25 to 147.
Angiogenin- Encoded for by the ANG gene. It makes up the b and e chains of the 1a4y protein. It goes from residue numbers 25 to 147.

Revision as of 01:55, 27 February 2018

This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.
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Structure of la4y(A Ribonuclease Inhibitor-Angiogenin Complex)

Ribonuclease Inhibitor-Angiogenin Complex

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</StructureSection>

References

  1. ↑ Papageorgiou AC, Shapiro R, Acharya KR. Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution. EMBO J. 1997 Sep 1;16(17):5162-77. PMID:9311977 doi:10.1093/emboj/16.17.5162
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644

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