Sandbox Reserved 1328

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This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430.

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Ribonuclease Inhibitor-Angiogenin Complex

The ribonuclease inhibitor-angiogenin complex is a protein found in human placental cells. The ribonuclease inhibitor protein and angiogenin protein have a strong affinity for each other. The main gene that codes for the ribonuclease inhibitor is RNH1. Ribonuclease also inhibits other proteins such as RNASE1 and RNASE2, so it is also important in processing RNA. Angiogenin has a sequence length of 123 and its gene name is ANG or RNASE5.

Function

The complex is responsible for protein binding and positive regulation of phosphorylation. The ribonuclease inhibitor protein binds to the angiogenin complex, a blood-vessel inducing protein, to inhibit it. Angiogenin is able to promote growth of blood vessels by promoting rRNA transcription. Under normal growth conditions, ANG is located in the nucleus away from the ribonuclease inhibitor to allow for prolific rRNA transcription. However, during periods of stress nuclear ANG is associated with ribonuclease inhibitor in the cytoplasm. This allows ribonuclease inhibitor to inhibit ANG, and prevent excess rRNA transcription allowing for energy to be conserved.

Relevance

Angiogenin has been known to be involved in normal and tumor growth during angiogenesis. The presence of inhibitors, such as ribonuclease inhibitor, blocks angiogenin and limits blood vessel growth. This can therefore curb proliferation of cancer cells. Malfunctions in angiogenin are also a main cause of amyotrophic lateral sclerosis (ALS)

Structural highlights

The complex consists of two distinct protein molecules: ribonuclease inhibitor and angiogenin. The ribonuclease inhibitor has two chains, . The angiogenin molecule consists of two chains, . Chains C and F are correspond to the water molecules associated with the complex. The ribonuclease inhibitor molecule is particularly rich in repeats. Because the complex consists of the two molecules, there are sites of high interaction. The places of strongest contact are between the residue in angiogenin and in ribonuclease inhibitor.

References

https://www.rcsb.org/structure/1a4y https://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?dps=0&uid=1A4Y https://academic.oup.com/abbs/article/40/7/619/622 http://www.ebi.ac.uk/pdbe/entry/pdb/1a4y http://www.uniprot.org/uniprot/P13489 http://jcs.biologists.org/content/126/18/4308

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	== Structural highlights ==		== Structural highlights ==
-	The complex consists of two distinct protein molecules: ribonuclease inhibitor and angiogenin. The ribonuclease inhibitor has two chains, <scene name='77/777648/Chains_a_and_d/1'>A and D</scene>. The angiogenin molecule consists of two chains, <scene name='77/777648/Chains_b_and_e/1'>B and E</scene>. The ribonuclease inhibitor molecule is particularly rich in <scene name='77/777648/Leucine_2/1'>leucine</scene> repeats. Because the complex consists of the two molecules, there are sites of high interaction. The places of strongest contact are between the residue <scene name='77/777648/Lys40/1'>Lys40</scene> in angiogenin and <scene name='77/777648/Residues_434-460/1'>residues 434-460</scene> in ribonuclease inhibitor.	+	The complex consists of two distinct protein molecules: ribonuclease inhibitor and angiogenin. The ribonuclease inhibitor has two chains, <scene name='77/777648/Chains_a_and_d/1'>A and D</scene>. The angiogenin molecule consists of two chains, <scene name='77/777648/Chains_b_and_e/1'>B and E</scene>. Chains C and F are correspond to the water molecules associated with the complex. The ribonuclease inhibitor molecule is particularly rich in <scene name='77/777648/Leucine_2/1'>leucine</scene> repeats. Because the complex consists of the two molecules, there are sites of high interaction. The places of strongest contact are between the residue <scene name='77/777648/Lys40/1'>Lys40</scene> in angiogenin and <scene name='77/777648/Residues_434-460/1'>residues 434-460</scene> in ribonuclease inhibitor.

Sandbox Reserved 1328

From Proteopedia

Revision as of 02:07, 27 February 2018

Ribonuclease Inhibitor-Angiogenin Complex

Function

Relevance

Structural highlights

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