Sandbox Reserved 1387
From Proteopedia
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== Function == | == Function == | ||
The main function of this protein is glucose transmembrane transport. It is one of fourteen facilitative sugar transporters. <ref>https://www.ebi.ac.uk/pdbe/entry/pdb/5c65</ref> | The main function of this protein is glucose transmembrane transport. It is one of fourteen facilitative sugar transporters. <ref>https://www.ebi.ac.uk/pdbe/entry/pdb/5c65</ref> | ||
| - | GLUT3 is categorized as a Class I transporter due to its protein sequence and structural similarity to other glucose transporters grouped in Class I. GLUT3 displays the highest affinity for glucose of all of the Class I glucose transporters and has a transport capacity five times greater than that of GLUT1 and GLUT4<ref>DOI 10.1152/ajpendo.90388.2008</ref>. | + | GLUT3 is categorized as a Class I transporter due to its protein sequence and structural similarity to other glucose transporters grouped in Class I. GLUT3 displays the highest affinity for glucose of all of the Class I glucose transporters and has a transport capacity five times greater than that of GLUT1 and GLUT4<ref>DOI 10.1152/ajpendo.90388.2008</ref>. |
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| + | GLUT3 is found predominantly in brain tissue, almost always expressed by neurons. The location of GLUT3 has led to it sometimes being called the "neuronal glucose transporter". | ||
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| + | Its main function is to act in the transmembrane region to create channels for glucose to move across the cell membrane. | ||
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | GLUT3 has 481 amino acids, which compose 28 alpha helices. | + | GLUT3 has 481 amino acids, which compose 28 alpha helices. It weighs approximately 52,520 Daltons which is equivalent to 8.72115e-20 grams<ref>https://www.ebi.ac.uk/pdbe/entry/pdb/5c65</ref>. |
Its <scene name='77/777707/Hydrophobic_binding_sites/2'>Hydrophobic Binding Sites</scene> are Leucine, Alanine, Phenylalanine, Isoleucine. | Its <scene name='77/777707/Hydrophobic_binding_sites/2'>Hydrophobic Binding Sites</scene> are Leucine, Alanine, Phenylalanine, Isoleucine. | ||
Revision as of 03:02, 27 February 2018
| This Sandbox is Reserved from January through July 31, 2018 for use in the course HLSC322: Principles of Genetics and Genomics taught by Genevieve Houston-Ludlam at the University of Maryland, College Park, USA. This reservation includes Sandbox Reserved 1311 through Sandbox Reserved 1430. |
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Homo sapien Glucose Transporter GLUT3 / SLC2A3
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ https://www.ebi.ac.uk/pdbe/entry/pdb/5c65
- ↑ Simpson IA, Dwyer D, Malide D, Moley KH, Travis A, Vannucci SJ. The facilitative glucose transporter GLUT3: 20 years of distinction. Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E242-53. doi:, 10.1152/ajpendo.90388.2008. Epub 2008 Jun 24. PMID:18577699 doi:http://dx.doi.org/10.1152/ajpendo.90388.2008
- ↑ https://www.ebi.ac.uk/pdbe/entry/pdb/5c65
