5mto
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==N-terminal domain of the human tumor suppressor ING5 C19S mutant== | |
| - | + | <StructureSection load='5mto' size='340' side='right' caption='[[5mto]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5mto]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MTO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MTO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mto FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mto OCA], [http://pdbe.org/5mto PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mto RCSB], [http://www.ebi.ac.uk/pdbsum/5mto PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mto ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ING5_HUMAN ING5_HUMAN]] Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator.<ref>PMID:12750254</ref> <ref>PMID:16387653</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Blanco, F J]] | ||
| + | [[Category: Buitrago, J A.R]] | ||
| + | [[Category: Ormaza, G]] | ||
| + | [[Category: Rojas, A L]] | ||
| + | [[Category: Roversi, P]] | ||
| + | [[Category: Ing5]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Tumor suppressor]] | ||
Revision as of 06:13, 28 February 2018
N-terminal domain of the human tumor suppressor ING5 C19S mutant
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